Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
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چکیده
authors neglected to indicate that the same results were also reported by Parmigiani et al. (reference 31), but in that paper the relevant data are not shown. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
منابع مشابه
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
Sestrins are stress-inducible metabolic regulators that suppress a wide range of age- and obesity-associated pathologies, many of which are due to mTORC1 overactivation. Upon various stresses, the Sestrins inhibit mTORC1 activity through an indirect mechanism that is still unclear. GATORs are recently identified protein complexes that regulate the activity of RagB, a small GTPase essential for ...
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mTORC1 is a master regulator of cell growth that responds to diverse environmental inputs and is deregulated in human diseases, such as cancer and epilepsy. One important input to this system is amino acids, such as leucine, which require the Rag GTPases and its regulators, including GATOR1 and GATOR2, to modulate mTORC1 activity. How amino acids, specifically leucine, are directly sensed, howe...
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